Most Recent Publications
Paper Publication: Networks of worry—towards a connectivity-based signature of late-life worry using higher criticism
Severe worry is a complex transdiagnostic phenotype independently associated with increased morbidity, including cognitive impairment and cardiovascular diseases. We investigated the neurobiological basis of worry in older adults by analyzing resting state fMRI using a large-scale network-based approach.
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Dr. Carmen Andreescu’s Interview with NYT
The New York Times recently interviewed Dr. Carmen Andreescu regarding her work in FINA and RAW. An excerpt below: Underdiagnosis also stems from older patients’ reluctance to ascribe their problems to psychological issues. “Some resent a label of ‘anxious,’” Dr. Andreescu said. “They’d rather call it ‘high stress,’ something that doesn’t indicate psychological weakness.” And […]
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New Paper: MRI predictors of pharmacotherapy response in major depressive disorder
We recently published a paper, first-authored by our postdoc Dr. Andrew Gerlach, on MRI predictors of antidepressant treatment outcome. This review covers structural and functional MRI, finding that region-specific measures such as increased hippocampal volume and decreased amygdala activation to negative stimuli were the most reliable predictors, though they lacked in specificity. Though currently divergent […]
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ARGO at OHBM
Drs. Carmen Andreescu, Helmet Karim, and Andrew Gerlach attended the Organization for Human Brain Mapping annual conference in Glasgow, Scotland. Drs. Karim and Gerlach presented their posters “Independent Replication of Advanced Brain Aging in Preclinical and Advanced Alzheimer’s Disease” and “Sex Moderates the Relationship between Functional Connectivity and Remission in Late-life Depression”. In addition to […]
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ARGO at Society of Biological Psychiatry (SOBP)
Dr. Carmen Andreescu presented at SOBP 2022 last week with a presentation titled: “Worried to Death – The Effects of Worry, Anxiety and Rumination on Brain Aging” in the symposium “Accelerated Biological aging: A Geroscience-Focus Approach to Understanding Brain Health and Late-Life Psychiatric Disorders Mechanisms and Outcomes.” This covered our recent work investigating the negative […]
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Paper Featured on Pitt Psychiatry: New Research on the Intricate Nature of Worry’s Neural Signature
A recent ARGO publication was featured on the front page of the University of Pittburgh’s Psychiatry Department’s website. Below is an excerpt: Severe worry is a complex transdiagnostic phenotype independently associated with increased morbidity, including cardiovascular diseases, cognitive impairment, and accelerated brain aging. A group of investigators, including Pitt Psychiatry scientists Andrew Gerlach, PhD (postdoctoral scholar); Helmet Karim, […]